Treatise on Poisons by Sir Robert Christison

4. Lastly, the poison which has been absorbed into the system, and may

1994 words  |  Chapter 28

consequently be detected in certain circumstances in the textures of the body at a distance from the alimentary canal, may also be removed beyond the reach of analysis, by being gradually discharged along with the excretions. It has been fully proved in recent times, that in poisoning with arsenic the poison may be found in ordinary cases, for some days after being swallowed, in the liver especially, but also in the other textures, in the blood, and in the urine; but that if a flow of urine be established and kept up, in nine or ten days, and sometimes much sooner, it can no longer be discovered anywhere by the nicest analysis.[102] _Is the discovery of poison in the body or the evacuations essential to establish a charge of poisoning?_ It was mentioned at the commencement of the present section, that the chemical evidence is generally, and correctly, considered the most decisive of all the branches of proof in cases of poisoning. But some toxicologists have even gone so far as to maintain that without chemical evidence, or rather, in more general terms, without the discovery of poison either in the body itself or in the evacuations,—no charge of poisoning ought to be held as proved. This, however, is a doctrine to which I cannot assent. In the preceding observations on the evidence of general poisoning it has been several times alluded to as unsound; and repeated opportunities of establishing exceptions will occur in the course of this work, under the head of individual poisons. At present it may be well to illustrate its unsoundness in reference to those charges of poisoning, where no particular poison is pointed at by the medical evidence, but where a whole class of poisons must be kept more or less in view. Even here I apprehend there may be sufficient evidence in the symptoms and morbid appearances, without any chemical facts,—to render poisoning so highly probable, that in conjunction with strong moral evidence, no sensible man can entertain any doubt on the subject. Several illustrations might be here given; and some will be found scattered throughout the work. In the present place a few instances will be mentioned which cannot be conveniently arranged any where else, and which are well worthy of notice, as being striking examples of the decision of questions of poisoning without chemical evidence. A man of doubtful character and morals, well acquainted with chemistry and medical jurisprudence, and of disordered finances, was known to harbour a design on a friend’s wife, who possessed a considerable fortune. At last he one morning invited the husband to breakfast with him at a tavern; and they breakfasted, in a private apartment, on beef-steaks, fried potatoes, eels, claret, and rum. They had scarcely commenced the meal when his guest complained of feeling unwell; and soon afterwards he vomited violently. This symptom continued, along with excruciating pain in the belly, for a long time before the prisoner sent for medical aid; indeed he did not procure a physician till the sufferer had been also attacked with very frequent and involuntary purging. The physician, who, before seeing his patient, had received the prisoner’s explanation of the apparent cause of the illness, was led at first to impute the whole to cholera caught by exposure to cold; but on returning at seven in the evening, and finding the gentleman had been dead for an hour, he at once exclaimed that he had been poisoned. On the body being inspected much external lividity was found, contraction of the fingers, and great inflammation of the stomach and intestines, presenting an appearance like that of gangrene.[103] On analyzing some fluid left in the stomach, no arsenic or other poison could be detected. The attention of the inspectors was turned specially to arsenic, because the prisoner was proved to have bought that poison, and to have made a solution of some white powder in his kitchen not long before the deceased died. The prisoner in his defence stated, that the deceased had been for some time much weakened by the use of mercury, and while in this state was seized with cholera; and he likewise attempted to make it probable that the man, in despair at his not recovering from a venereal disease, might have committed suicide. The council of physicians who were required to give their opinion on the case state on the contrary, that the diseased was a healthy man, without any apparent disposition to disease; that there was no pretext whatever for supposing suicide; that the inflammatory state of the stomach and bowels supplied strong probability of poisoning with arsenic, but not certain evidence; that acute gastritis from natural causes is always attended with constipation; that the deceased presented symptoms of stupor and other signs of derangement of the nervous system remarked in rapid cases of poisoning with arsenic; that cholera is very rare at the end of November, the season when this incident occurred; and that the poison might well be discharged by vomiting. Although all the prisoner’s statements in defence were contradicted by satisfactory proof, and the medical evidence of poisoning was supported by a chain of the strongest general circumstances, the crime was considered by the court as not fully proved, because the prisoner could not be induced to confess, and because poison was not actually detected in the body. But on account of the very strong probability of his guilt, he was, in conformity with the strange practice of German courts in the like cases, condemned to fifteen years’ imprisonment.[104] In this instance—considering the kind of symptoms, their commencement during a meal, the rapidity of death, the signs of violent inflammation in the stomach after so short an illness, and the facility with which the absence of poison in the contents of the stomach may be accounted for, more especially if it be supposed that the poison was administered in solution,—I consider the medical evidence of death by poisoning so very strong, that, the general evidence being also extremely strong, the prisoner’s guilt was fully demonstrated. A case of the same kind, but of still greater interest, is that of Mary Anne M’Conkey, who was tried at the Monaghan Assizes in 1841 for the murder of her husband. I am indebted for the particulars to Dr. Geoghegan, one of the principal Crown witnesses. The prisoner who had been too intimate with another man, and had been heard to express her intention of getting rid of her husband, was observed one day before dinner to separate some greens for him from the plateful intended for the rest of the family. None of the latter suffered at all. But her husband was taken violently ill immediately after dinner, and died; and a neighbour accidentally present, who partook, though sparingly, of the same dish with him, was also similarly and violently affected but recovered. The deceased before finishing the greens said they had a disagreeable sharp taste, and was seized soon after with burning at the heart, tenderness at the pit of the stomach, vomiting, coldness, a sense of biting in the tongue and tingling through the whole flesh, excessive restlessness, occasional incoherence, locked-jaw, clenching of the hands, and frothing at the mouth; and he expired three hours after the meal. His neighbour, two minutes after finishing his greens, experienced a sense of pricking in the mouth and burning in the throat, gullet, and stomach; then salivation, a feeling of swelling in the face without actual fulness, general numbness and creeping in the skin; next excessive restlessness, coldness of the integuments, dimness of sight, and stupor; about an hour after the meal he became speechless, repeatedly fainted, frothed at the mouth, and clenched his hands; vomiting ensued, with considerable relief, and subsequently he had frequent attacks of it, with purging, tenderness of the epigastrium, cramps, and tingling in the flesh; and from these symptoms he recovered so slowly as to be unable to work for five weeks. The only morbid appearance of any note in the body of the deceased was a number of irregular brownish-black patches on the inside of the stomach. No poison could be detected in the contents or tissues of the stomach; none could be discovered in the house except a corrosive-sublimate solution which the prisoner used for a gargle; and none could be traced into her possession. A variety of circumstances of a general nature, which are passed over here for brevity, as not strictly appertaining to the present view of the case, threw very great suspicion over the prisoner. The medical witnesses deposed, that poisoning could alone explain the medical circumstances; and Dr. Geoghegan was of opinion that death was owing to some vegetable poison, although he could not specify the particular substance. He suspected, however, that it was monkshood. In these views, when consulted by him before the trial, I entirely concurred. Considering the taste observed by the deceased at the time he ate the greens, the rapidity with which he was taken ill afterwards, and the very peculiar symptoms, unlike those of any natural disease with which physicians are acquainted, and agreeing with those which are produced by monkshood,—considering also that another individual, who partook of the same dish with him, was similarly and simultaneously attacked, and with a severity proportioned to the quantity he took, while other persons who ate the same food from a different dish, did not suffer at all,—it appears to me that poisoning was clearly established; and I also think that the general evidence brought home the charge of administering the poison to the prisoner. She was condemned and executed, and confessed before execution, that she did poison her husband, and that the substance she used was the powdered root of monkshood, which is well known as a poison to the peasantry of Monaghan under the name of Blue Rocket. It is scarcely necessary to add, that great caution must be observed in applying the general principle here inculcated. But the opposite doctrine, that no charge of poisoning can be established without the discovery of poison in the body or in the evacuations, appears to me a great error, though upheld by no mean authority. Under that doctrine few criminals would be brought to justice, were they to resort to a variety of vegetable poisons, which in certain seasons are within the reach of every one. SECTION IV.—_Evidence from Experiments on Animals._ Evidence from experiments on animals with articles supposed to contain poison is more equivocal than was once imagined. But it may be doubted whether some medical jurists have not overstepped the proper limits, when they hold it to constitute little or no proof at all. Evidence from express experiments should rarely form part of a regular medical inquiry into a charge of poisoning. For in the first place, to make sure of performing an experiment well requires more experimental skill than the generality of practitioners can be expected to possess; then, as will seen in the sequel, evidence procured from this source can very rarely be more than presumptive; and lastly, if the quantity of poison in the suspected substance is great enough to affect one of the perfect animals, it may generally be recognized to a certainty by its physical or chemical properties. For these reasons it is not likely, that, in an inquiry undertaken by a skilful toxicologist, he will put himself in the way of delivering an opinion on the force of such evidence. But it is nevertheless necessary for me to consider it in detail, because he may have to give his opinion regarding experiments made inconsiderately by others, or accidents caused by domestic animals eating the remains of substances suspected to be poisoned. The matter subjected to trial may be either suspected food, drink, or medicine; or it may be the stuff vomited during life, or found in the stomach after death; or it may be the flesh of poisoned animals.

Chapters

1. Chapter 1 2. PART II.—OF INDIVIDUAL POISONS. 3. CHAPTER I. 4. 1. _On the Action of Poisons through Sympathy._ In the infancy of 5. 2. _Of the Action of Poisons through Absorption._—If doubts may be 6. 1. _Quantity_ affects their action materially. Not only do they produce 7. 2. _As to state of aggregation_,—poisons act the more energetically the 8. 3. The next modifying cause is _chemical combination_. This is sometimes 9. 4. The effect of _mixture_ depends partly on the poisons being diluted. 10. 5. _Difference of tissue_ is an interesting modifying power in a 11. 6. With respect to differences arising from _difference of organ_, these 12. 7. _Habit and Idiosyncrasy._—The remarks to be made under the present 13. 8. The last modifying cause to be mentioned comprehends certain 14. CHAPTER II. 15. 1. The first characteristic is the _suddenness of their appearance and 16. 2. The next general characteristic of the symptoms of poisoning is 17. 3. Another characteristic is _uniformity in the nature of the symptoms_ 18. 4. The fourth characteristic is, that _the symptoms begin soon after a 19. 5. Lastly, _the symptoms appear during a state of perfect health_. This 20. 1. As to the _suddenness of their invasion and rapidity of their 21. 2. As to the uniformity or _uninterrupted increase of the symptoms_, it 22. 3. It was stated above, that the third character, _uniformity in kind_ 23. 4. In the next place, it was observed that some reliance may be placed 24. 5. Little need be said with regard to _the symptoms beginning, while the 25. 1. It may have been discharged by vomiting and purging. Thus on the 26. 2. The poison may have disappeared, because it has been all absorbed. It 27. 3. Poisons may not be found, because the excess has been decomposed. 28. 4. Lastly, the poison which has been absorbed into the system, and may 29. 1. The evidence derived from _the effects of suspected food, drink, or 30. 2. In the case of _the vomited matter_ or _contents of the stomach_ 31. 3. The effects of _the flesh of poisoned animals_, eaten by other 32. 3. The next article, which relates to the proof of the administration of 33. 4. The next article in the moral evidence relates to the intent of the 34. 5. The next article among the moral circumstances,—the simultaneous 35. 6. The next article of the moral evidence relates to suspicious conduct 36. CHAPTER III. 37. CHAPTER I. 38. 1. _Arsenical_ White arsenic 185 39. 2. _Acids_ Sulphuric acid 32 40. 3. _Mercurials_ Corrosive sublimate 12 41. 4. _Other mineral irritants_ Tartar-emetic 2 42. 5. _Veget. irritants_ Colchicum 3 43. 7. _Opium_ Opium or Laudan. 180 44. 8. _Hydrocyanic acid_ Med. Hydroc. acid 27 45. 9. _Other veget. Narcotics_ Nux-vomica 3 46. 11. Unascertained 22 47. CHAPTER II. 48. 1. _Distension of the Stomach._—Mere distension of the stomach from 49. 2. _Rupture of the Stomach_ is not a common occurrence; but it sometimes 50. 3. _Rupture of the Duodenum_ is a very rare accident from internal 51. 4. Under the next head may be classed rupture of the other organs of the 52. 5. The next accident which may be noticed on account of its being liable 53. 6. _Of Bilious Vomiting and Simple Cholera._—Of all the diseases which 54. 7. _Of Malignant Cholera._—The history of this disease affords a fair 55. 8. _Of Inflammation of the Stomach._—Chronic inflammation of the stomach 56. 9. _Inflammation of the Intestines_ in its acute form is more common 57. 10. _Inflammation of the Peritonæum_, or lining membrane of the belly, 58. 11. The subject of _Spontaneous Perforation of the Stomach_ is an 59. 12. The _gullet_ may be perforated in a similar manner either with or 60. 13. _Perforation of the alimentary canal by worms_ may here also be 61. 14. The next diseases to be mentioned are melæna and hæmatemesis, or 62. 15. The last are _colic_, _iliac passion_, and _obstructed intestine_. 63. CHAPTER III. 64. 1. _When concentrated_ it is oily-looking, colourless, or brownish from 65. 2. _When diluted_, it may be distinguished from all ordinary acids by 66. 3. It is seldom that the medical jurist is called on to search for 67. 1. The most ordinary symptoms are those of the first variety,—namely, 68. 2. The second variety of symptoms belong to a peculiar modification of 69. 3. The third variety includes cases of imperfect recovery. These are 70. 4. The last variety comprehends cases of perfect recovery, which are 71. 1. _When concentrated_, nitric acid is easily known by the odour of its 72. 2. _In a diluted state_ this acid is not so easily recognised as the 73. 3. _When in a state of compound mixture_, nitric acid, like sulphuric 74. 1. Hydrochloric acid, _in its concentrated state_, is colourless, if 75. 2. _When diluted_, it is recognised with facility, first by 76. 3. In the last edition of this work I proposed for the detection of 77. CHAPTER IV. 78. CHAPTER V. 79. CHAPTER VI. 80. 1. In the form of a pure solution, its nature may be satisfactorily 81. 2. The only important modifications in the analysis rendered necessary 82. CHAPTER VII. 83. CHAPTER VIII. 84. CHAPTER IX. 85. CHAPTER X. 86. CHAPTER XI. 87. CHAPTER XII. 88. CHAPTER XIII. 89. 3. The arsenite of copper, or _mineral green_. 4. The arsenite of potass 90. 2. _Of the Tests for Arsenious Acid._ 91. 7. After the precipitate has thoroughly subsided, the supernatant liquid 92. introduction as a poison into the body. This topic, one of paramount 93. 1. _Arsenic may exist as an adulteration in some reagents._—It must be 94. 2. _Arsenic may be present in some articles of chemical 95. 3. _Arsenic may have existed in antidotes administered during life._—It 96. 4. _Arsenic sometimes exists naturally in the human body._—This 97. 5. _Arsenic may exist in the soil of churchyards._—This proposition too 98. 3. _Arsenite of Copper_. 99. 4. _Arsenite of Potass_. 100. 5. _Arseniate of Potass._ 101. 6. _The Sulphurets of Arsenic._ 102. 7. _Arseniuretted-Hydrogen._ 103. 1. In one order of cases, then, arsenic produces symptoms of irritation 104. 2. The second variety of poisoning with arsenic includes a few cases in 105. 3. The third variety of poisoning with arsenic places in a clear point 106. CHAPTER XIV. 107. 1. _Of Red Precipitate._ 108. 2. _Of Cinnabar._ 109. 3. _Of Turbith Mineral._ 110. 4. _Of Calomel._ 111. 5. _Of Corrosive Sublimate._ 112. 1. _Hydrosulphuric acid gas_ transmitted in a stream through a solution 113. 1. _Lime-Water_ throws down the binoxide of mercury in the form of a 114. 6. _Of Bicyanide of Mercury._ 115. 7. _Of the Nitrates of Mercury._ 116. 1. The symptoms in the first variety are very like what occur in the 117. 2. The second variety of poisoning with mercury comprehends the cases, 118. 3. The third variety of poisoning with mercury comprehends all the forms 119. introduction of corrosive sublimate into the stomach. The poison then 120. CHAPTER XV. 121. 1. _Mineral Green._ 122. 2. _Natural Verdigris._ 123. 3. _Blue Vitriol._ 124. 1. _Ammonia_ causes a pale azure precipitate, which is redissolved by an 125. 2. _Sulphuretted hydrogen gas_ causes a dark brownish-black precipitate, 126. 3. _Ferro-cyanate of potass_ causes a fine hair-brown precipitate, the 127. 4. A polished rod or plate of _metallic iron_, held in a solution of 128. 4. _Artificial Verdigris._ 129. 1. Should the subject of analysis not be a liquid, render it such by 130. 2. If the copper be extremely minute in quantity, sulphuretted hydrogen 131. CHAPTER XVI. 132. 1. _Caustic potass_ precipitates a white sesquioxide, but only if the 133. 2. _Nitric acid_ throws down a white precipitate, and takes it up again 134. 3. The _Infusion of Galls_ causes a dirty, yellowish-white precipitate; 135. 4. The best liquid reagent is _Hydrosulphuric acid_. In a solution 136. 5. When the solution is put into Marsh’s apparatus for detecting arsenic 137. 1. Subject a small portion of the liquid to a stream of hydrosulphuric 138. 2. If hydrosulphuric acid do not distinctly affect the liquid, or if no 139. 3. If antimony be not indicated in either of these ways in the fluid 140. CHAPTER XVII. 141. CHAPTER XVIII. 142. 1. _Of Litharge and Red Lead._ 143. 2. _Of White Lead._ 144. 3. _Of Sugar of Lead._ 145. 1. _Hydrosulphuric acid_ causes a black precipitate, the sulphuret of 146. 2. _Chromate of potass_, both in the state of proto-chromate and 147. 3. _Hydriodate of potass_ causes also a lively gamboge-yellow 148. 4. _A rod of zinc_ held for some time in the solution displaces the 149. 4. _Goulard’s Extract._ 150. introduction of lead into the body; and in the last the whole course of 151. introduction of lead into the body may be presumed to be the real cause. 152. introduction of lead into the system. Dr. Burton thinks it will when the 153. CHAPTER XIX. 154. CHAPTER XX. 155. CHAPTER XXI. 156. CHAPTER XXII. 157. CHAPTER XXIII. 158. CHAPTER XXIV. 159. CHAPTER XXV. 160. CHAPTER XXIV. 161. 1. Apoplexy is sometimes preceded at considerable intervals by warning 162. 2. Apoplexy attacks chiefly the old. It is not, however, confined to the 163. 3. The next criterion is, that apoplexy occurs chiefly among fat people. 164. 4. A fourth criterion is drawn from the relation which the appearance of 165. 5. Another criterion relates to the progress of the symptoms. The 166. 6. Although there is a great resemblance between the symptoms of 167. 7. In the last place, a useful criterion may be derived from the 168. 1. The epileptic fit _is sometimes preceded by certain warnings_, such 169. 2. The symptoms of the epileptic fit _almost always begin violently and 170. 3. As in apoplexy, so in epilepsy the patient _in general cannot be 171. 4. When a person dies in a fit of epilepsy, _the paroxysm generally 172. 5. M. Esquirol, a writer of high authority, says that epilepsy _very 173. CHAPTER XXVII. 174. 1. If there be any solid matter, it is to be cut into small fragments, 175. 2. Add now the solution of acetate of lead as long as it causes 176. 3. The fluid part is to be treated with hydrosulphuric acid gas, to 177. 4. It is useful, however, to separate the meconic acid also; because, as 178. 5. If there be a sufficiency of the original material, Merck’s process 179. 546. There is little doubt that poisoning with opium may cause 180. CHAPTER XXVIII. 181. CHAPTER XXIX. 182. CHAPTER XXX. 183. CHAPTER XXXI. 184. 1. M. Chomel of Paris has related a case of poisoning with the gas 185. 2. The fumes of burning charcoal have been long known to be deleterious. 186. 3. It is probable that in some circumstances a very small quantity of 187. 4. The vapours from burning coal are the most noxious of all kinds of 188. 5. Somewhat analogous to the symptoms now described are the effects of 189. CHAPTER XXXII. 190. CHAPTER XXXIII. 191. CHAPTER XXXIV. 192. CHAPTER XXXV. 193. CHAPTER XXXVI. 194. CHAPTER XXXVII. 195. CHAPTER XXXVIII. 196. CHAPTER XXXIX. 197. CHAPTER XL. 198. CHAPTER XLI. 199. 1. When the dose is small, much excitement and little subsequent 200. 2. When the effect is sufficiently great to receive the designation of 201. 160. In twenty-four hours more the breathing became laborious and 202. 3. The third degree of poisoning is not so often witnessed, because, in 203. CHAPTER XLII. 204. 1. _Poisoning with Arsenic and Alcohol._—A man, after taking twelve 205. 3. _Poisoning with Tartar-Emetic and Charcoal Fumes._—Under the head of 206. 4. _Poisoning with Alcohol and with Laudanum._—Under the head of 207. 5. _Poisoning with Laudanum and Corrosive Sublimate._—Of all the cases 208. 6. _Poisoning with Opium and Belladonna._—A lady, who used a compound 209. 7. In the following cases, the active poisons to which the individuals 210. 2. Apparatus for the distillation of fluids suspected to contain 211. 3. Tube for reducing very small portions of arsenic or mercury. The 212. 4. A small glass funnel for introducing the material into the tube 213. 5. The ordinary apparatus for disengaging sulphuretted-hydrogen. The 214. 6. Instrument for washing down scanty precipitates on filters. It is a 215. 7. Tubes of natural size for collecting small portions of mercury by 216. 8. Pipette, one-fourth the natural size, for removing by suction 217. 9. Apparatus for reducing the sulphurets of some metals by a stream of 218. 36. Quoted by Marx, die Lehre von den Giften, I. ii. 163. 219. 92. Vicarius, Ibidem, Obs. 100. Riselius, Ibidem, Dec. i. An. v. Obs. 220. 1762. See Marx, i. ii. 29. 221. 1. P. 476, changed “exasperated by the use of oil” to “exacerbated by 222. 2. P. 513, changed “I may here add a very opposite instance of 223. 6. Enclosed italics font in _underscores_.

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