1551. Sweating sickness of the original sort was never again the _signum

pathognomicum_ of a whole epidemic of fever. The English Sweat became an extinct species, after a comparatively brief existence on the earth of sixty-six years. Its successors among the forms of pestilential disease may have occasionally put forth the sweating character, as if in a sport of nature; but the most of the travelling, or posting, or universal fevers, and universal colds, are easily distinguished from the sweat--_nova febrium terris incubuit cohors_[526]. Antecedents of the English Sweat. The history of the English sweat presents to the student of epidemics much that is paradoxical although not without parallel, and much that his research can never rescue from uncertainty. Where did this hitherto unheard of disease come from? Where was it in the intervals from 1485 to 1508, from 1508 to 1517, from 1517 to 1528, and from 1528 to 1551? What became of it after 1551? Why did it fall mostly on the great houses,--on the king’s court, on the luxurious establishments of prelates and nobles, on the richer citizens, on the lusty and well fed, for the most part sparing the poor? Why did it avoid France when it overran the Continent in 1529? No theory of the sweat can be held sufficient which does not afford some kind of answer to each of those questions, and some harmonizing of them all. The history of Polydore Virgil is so well informed on all that relates to the arrival in England of Henry VII. that we may accept as the common belief of the time his two statements about the sweat, the first associating it in some vague way with the descent of Henry upon Wales, and the second pronouncing it a disease hitherto unheard of in England. Caius, who wrote in 1552 and 1555, and can have had no other knowledge of the events of 1485 than is open to a historical student of to-day, said that the sweat “arose, so far as can be known, in the army of Henry VII., part of which he had lately brought together in France, and part of which had joined him in Wales.” Hecker, the modern reconstructer of the history (1834), has passed from the tradition of Polydore Virgil and of Caius, clean into the region of conjecture in assuming that the sweat had arisen among the French mercenaries on the voyage and on the march to Bosworth. On the other hand, the one contemporary medical writer in 1485, Forrestier, is explicit enough in his statement that the sweat “first unfurled its banners in England in the city of London, on the 19th of September,” or some three weeks after Henry’s entry into the city. There is nowhere a hint that it was prevalent among the troops, whether French, Welsh or English, who won the battle of Bosworth on the 22nd of August, the only pretext for asserting that it was prevalent in the neighbourhood before the battle being the gossip of the Croyland chronicle concerning lord Stanley’s excuse to Richard III. for not bringing up his men, which gossip probably arose soon after when the sweat became notorious. Croyland was not very far from the camp of the Stanleys; and yet we know for certain (with the help of the state papers) that the death of the abbot Lambert Fossedike from the sweat happened there after an illness of eighteen hours on the 14th October, some seven or eight weeks from the date of Bosworth Field, and some three or four weeks after the outbreak of the disease in London. The probabilities of the case are all in favour of Forrestier’s view that the first of the sweat in 1485 was its appearance in London; and we shall accordingly take that as our point of departure. Henry covered the distance between Leicester and London in four days, having left the former, after a rest of two nights, on the Wednesday, slept at St Albans on the Friday, and entered London, very tired by his journey (says Bernard André), on Saturday evening, 27th August, three weeks to a day from his landing at Milford Haven. Whether his whole force travelled from Leicester at the same pace, and entered the city with him, does not appear; but it can hardly be doubted that Henry’s following, French, Welsh and English, had found their way to London without loss of time, to make personal suit for the grants and patents that began to be issued under the royal seal in immense numbers after the first or second week in September. London must have been unusually full of people in the weeks before the Coronation on the 30th October. But the pestilence that broke out was not the “common infection” or plague, which might intelligibly have been fanned into a flame by a great concourse of people. It was the sweat,--a new disease, a stranger not only to England but to all the world. We shall understand the mysteriousness of the visitation and the inadequacy of all ordinary explanations, by taking Forrestier’s account of the causes of it, drawn up in the year of its first occurrence. Although this earliest writer on the sweat recognized its distinctive type quite clearly, making no confusion between it and the plague, yet he referred both diseases to the same set of causes; and in his section on the causes of the sweat he merely reproduces the conventional list of nuisances which occurs in nearly all treatises on the plague before and after his time. There was little variation from that list, as it is given in the last chapter from a plague-book of the 14th century, down even to the reign of Elizabeth; thus it is reproduced almost word for word in Bullein’s _Dialogue on the Fever Pestilence_ written in 1564 (the year after a great plague), and it is so uniform in Elyot’s _Castle of Health_, in Phaer’s, and in all the other hygienic manuals of the time, that it might almost have been stereotyped. This was the causation which Forrestier transferred bodily to the sweat in his manuscript of 1485; almost the same causation had been given in the old essay of the bishop of Aarhus on the plague, actually printed in London in 1480. “The causes of this sickness,” he says, “be far and nigh. The far causes--they be the signs or the planets, whose operation is not known of leeches and of phisitions; but of astronomers they be known.... The nigh causes be the stynkynge of the erthe as it is in many places.... For these be great causes of putrefaction: and this corrupteth the air, and so our bodies are infect of that corrupt air.... And it happeneth also, that specially where the air is changed into great heat and moistness, they induceth putrefaction of humours, and namely in the humours of the heart; and so cometh this pestilence, whose coming is unknown, as to them that die sodenley, &c.” Among the causes of the corruption he specially mentions the following, which probably had a real existence in the London of that time, although he is merely reproducing a stock paragraph of foreign origin: “And of stinking carrion cast into the water nigh to cities or towns,--as the bellies of beasts and of fishes, and the corruption of privies--of this the water is corrupt. And when as meat is boiled, and drink made of the water, many sickness is gendered in man’s body; and [so] also of the casting of stinking waters and many other foul things in the streets, the air is corrupt; and of keeping of stinking matters in houses or in latrines long time; and then, in the night, of those things vapour is lift up into the air, the which doth infect the substance of the air, by the which substance the air corrupts and infects men to die suddenly, going by the streets or by the way. Of the which thing let any man that loveth God and his neighbour amend.” He then mentions a more distant source of corrupt air, apt to be carried on the wind--the corruption of unburied bodies after a battle, which enters into all the plague-writings of the time. These things were, of course, insufficient to account for the special type of the sweat, or for its sudden outbreak, for the first time in history, in September, 1485. There may have been such favouring conditions in London at the time; something of the kind is indeed implied in Henry VII.’s order against the nuisance of the shambles a few years after; but we require a special factor, without which the unsavoury state of the streets, lanes, yards, and ditches, or the crowded state of the houses, would never have come to an issue in so remarkable an infection as the sweating sickness. Common nuisances were the less relevant to the sweat, for the reason that it touched the well-to-do classes most, the classes who suffered least from the “common infection,” or “the poor’s plague,” and were presumably best housed, or located amidst cleanest surroundings. Even within the narrow limits of Old London there were preferences of locality. If the special incidence of the sweat upon the great households of prelates and nobles, and on the families of wealthy citizens, had rested only on the testimony of Dr Caius, who has a theory and a moral to work out, there might have been some reason for the scepticism of Heberden, who questions whether Caius was not probably in error in saying that the sweat spared the poor and the wretched, because he knows of no parallel instance among infective diseases[527]. But the fact is abundantly illustrated in the details, already given, for each of the five English epidemics; and it is confirmed for the continental invasion of 1529, e.g. by Kock, a parish priest of Lübeck, who says that “the poor people, and those living in cellars or garrets were free from the sickness,” and by Renner, of Bremen, who says that it “went most among the rich people[528].” It was, indeed, owing to its being an affliction chiefly of the upper classes that the sweat has been so much heard of. So far as mere numbers went, all the five London epidemics together could not have caused so great a mortality as the plague caused in a single year of Henry VII., namely the year 1500, or in a single year of Henry VIII., such as the year 1513. But these great mortalities from plague, amounting to perhaps a fifth part of the whole London population in a single season, fell mainly, although not of course exclusively, upon the poorer class. The bubo-plague, domesticated on English soil from 1348 to 1666, was emphatically the “poor’s plague,” and, as such, it illustrated the usual law of infective disease, namely that it specially befell those who were the worst housed, the worst fed, the hardest pressed in the struggle, and the least able to find the means of escaping to the country when the infection in the city gave warning of an outbreak on the approach of warm weather. But _morbus pauperum_ is not the only principle of infective disease. There are pestilent infections which do not come readily under the law of poor, uncleanly and negligent living, in any ordinary sense of the words; and there are some communicable diseases which directly contradict the principle that infection falls upon those who engender it by their mode of life. Unwholesome conditions of living may be trusted to engender disease, but it does not follow that the infection so engendered will fall upon those who lead the unwholesome lives; sometimes it falls upon the class who are farthest removed from them in social circumstances or domestic habits, or who are widely separated from them in racial characters. This principle I believe to be not only a necessary complement to the more obvious rule, but to be itself one of wide application. It has been an original theme of my own in former writings, to which I take leave to refer in a note[529]; and, I have now to try here whether it may not suit the rather paradoxical and certainly mysterious circumstances of the sweating sickness on its first outbreak in the autumn of 1485. If the insanitary state of London were insufficient to explain the engendering of the disease, the next thing is to look for a foreign source. Suspicion falls at once upon the foreign mercenaries who landed with Henry Tudor at Milford Haven on the 6th of August. Who were these mercenaries? Did they suffer from any contagious disease? Were they likely to have engendered the sweat? Can the infection be traced, in matter of fact, to them? In seeking an answer, it will be necessary to enter somewhat fully into the history of the expedition. The earl of Richmond’s successful expedition in 1485 was his second attempt on the English crown. The first had been made in 1483, when the duke of Gloucester was hardly seated on the throne and the duke of Buckingham was in the field against him. Richmond’s army on that occasion had been furnished by the duke of Brittany, and is roughly estimated at 5000 men in 15 ships[530]; the expedition sailed from St Malo in October, encountered a storm in the Channel which scattered the fleet, and drove some of the ships back to the harbours of Brittany and Normandy, so that Richmond, having reached the Dorset coast with only one or two ships, was unable to land in force. He returned to a Norman port, and nothing more is heard of his army of Bretons; during the next two years he appears to have been left with no other following than two or three English nobles, among them the earl of Oxford, who afterwards led a division of his army at Bosworth. After repeated solicitation, he obtained in 1485 a small body-guard (_leve praesidium_) from the regents of Charles VIII. at Paris, a few pieces of artillery, and money to help pay for the transport of 3000 or 4000 men. With these resources he betook himself to Rouen in the summer of 1485 and began to fit out his expedition. It would appear that he found some difficulty in making up his force to the intended full complement, and that he was urged by the impatience of his followers and the chance of a fair wind to leave the Seine with what force he had on the 31st of July. His force of Frenchmen, under his kinsman de Shandé (afterwards earl of Bath), consisted of only 2000 men, crowded on board a few ships. It is a fair inference that the men had been recruited in and around Rouen; we are told, indeed, by Mezeray that Normandy was at that time infested by bands of _francs-archers_ who had been licensed by Louis XI., and that the ministers of Charles VIII. gave them to Henry Tudor, to the number of 3000, regarding the proposed expedition of the latter as a good opportunity of ridding the province of Normandy of a lawless and disreputable soldiery[531]. These, then, were the mercenaries who landed at Milford Haven on the 6th of August, were at once marched through Wales to Shrewsbury and Lichfield, and took a principal part in the battle of Bosworth on the 22nd of August. They were Normans, who had become so great a pest to their own province that Charles VIII.’s ministers were induced to take up Henry Tudor’s cause partly with the intention of ridding French territory of them. Their quality is plainly indicated in the speech just before the battle by Richard III., which had been composed for Hall’s chronicle; only they were not Bretons, as the speech makes out; they were Normans, recruited for the expedition in Rouen and the surrounding country. I have given so much emphasis to the nationality of these mercenaries because the theory of the English sweat turns upon it[532]. More than two centuries after Bosworth Field, about the year 1717, when the English sweat had been long forgotten, an almost identical type of disease began to show itself among the villages and towns of that very region of France, the lower basin of the Seine, where the mercenaries of 1485 had been recruited. A form of Sweat afterwards endemic in Normandy. The Picardy sweat, which was first noticed as a disease of the soil about the year 1717, and has continued off and on down to recent years, was indigenous to the departments in the basin of the Seine, from the Pas de Calais to Calvados, with Rouen as a centre. Why that strange form of sickness should have sprung up there and continued, now in one town or village now in another, with few blank years for a century and a half, no one can venture to say. It was not the English sweat in all its circumstances; on the contrary it was only rarely epidemic over a large population or a large tract of country at once. It was ordinarily limited to one or two spots at a time, and in the individuals affected it ran a longer course than the English sweat had done. But whenever it did become widely prevalent it also became a short and sharp infection like the English sweat, causing in some years a very considerable number of deaths. Distinctively the Picardy sweat was a somewhat mild sickness of a week or more, seldom fatal, distinctively also of a single town or village, or small group of villages. It was not unknown in some other parts of France, such as the Vosges and Languedoc, in Bavaria and in Northern Italy; but in these other localities it has been much more occasional or even rare. Its distinctive habitat for a century and a half has been the lower basin of the Seine; and there it has been so steady at one point or another from year to year throughout the whole of that period that it may be said to be a disease of the soil, indigenous or domesticated, and depending for its periodic manifestations mostly upon vicissitudes of the seasons, as affecting probably the rise and fall of the ground-water. It has been more a disease of the well-to-do bourgeois class than of the very poor, and it has often shown a preference for the cleaner villages. It has been the subject of a very large number of French writings from the year 1717 down almost to the present date. Strange as this form of disease is, neither its circumstances nor its nosological characters are left in any doubt; it is at once mysterious and perfectly familiar[533]. Theory of the English Sweat. I have been at some pains to show that Henry Tudor’s mercenaries were enlisted in and around Rouen, or, in other words, they came from that very district of France in which the sweat, in a somewhat modified form, began to make its appearance as an endemic malady two hundred and thirty years after. If the sweat had not become an endemic or standing disease there, as if native to the soil, or if it had become equally a disease of all other parts of Europe, as typhoid fever has, the coincidence would have been less striking, and might have been made to appear altogether irrelevant by the long interval of more than two centuries between the one event and the other. If it were a mere coincidence, we should conclude that the same causes which established in Normandy in the 18th century a steady prevalence of a sweating sickness, not unlike the more familiar prevalence of typhoid, had been at work on English soil more than two centuries earlier, not indeed to establish a form of sweating sickness steadily prevalent from year to year in one place or another, like the plague, but to induce five sharp epidemic outbursts, within a period of sixty-six years, four of which outbursts began in London and extended probably over the whole country, while one began in Shrewsbury, travelled by stages to London, and spread all over England. And, as we are ignorant of the things which determine the type of the endemic sweat of Normandy or Picardy down to the present day, we can neither deny nor affirm that there may have been corresponding factors of disease at work in the England of Henry VII. By such a line of reasoning we are brought to a view of the English sweat which precludes all farther inquiry and makes a permanent blank or maze in our knowledge. Let us try, however, whether the facts of the case do not better fall in with the view that the English sweat had a real relation to the seats of the Norman and Picardy sweat, even at a time when that sweat had not come into existence as a definite form of disease, and although the French provinces appear to have been spared the invasion of the epidemic when it overran the rest of Northern Europe in 1529. The means of communication in 1485 was not wanting, namely the Norman soldiery of Henry VII. The tradition of their quality is preserved in the speech composed in Hall’s chronicle for Richard III. before the battle of Bosworth, and versified somewhat closely by Shakespeare: “A sort of vagabonds, rascals, and run-aways, A scum of Bretagnes, and base lackey peasants: ... Let’s whip these stragglers o’er the seas again; Lash hence these over-weening rags of France, These famished beggars, weary of their lives.” There is nothing incredible in the supposition that these men had brought a disease into London although they had not themselves presented the symptoms of that disease. Such importations are not unknown; the mystery hanging over them does not make them the less real. A well-known instance is the St Kilda boat-cold, “the wonderful story,” as Boswell says, “that upon the approach of a stranger all the inhabitants catch cold,” a story which Mr Macaulay, the author of the _History of St Kilda_, had been advised to leave out of his book. “Sir,” said Dr Johnson, “to leave things out of a book merely because people tell you they will not be believed, is meanness: Macaulay acted with more magnanimity.” The St Kilda influenza has been amply corroborated since then by parallel instances from the more remote islands of the Pacific, and by striking instances in veterinary pathology. Among the latter may be quoted the instance which has been heard of in Shropshire, of “sheep which have been imported from vessels, although themselves in a healthy condition, if placed in the same fold with others, frequently producing sickness in the flock[534].” But there is an instance on a vast scale from the United States, the instance of Texas cattle-fever, which has recurred so often, and has been so closely watched on account of the disastrous loss which it causes, that there is no room left to doubt the reality of that mysterious form of contagion. I shall have to speak very shortly of the malignant fevers of the assizes, which spread from prisoners who were not known to be ill of fever; these incidents are historical from the year 1522, when an epidemic of the kind arose among the court and grand jury at the gaol delivery in the Castle of Cambridge. Lastly the history of yellow fever, as expounded in part in this volume, is an instance of a long-enduring infection arising from the circumstances of the African slave-trade, the negroes themselves having been racially exempt from the fever although they had been the source of the virus. In all such cases the sickness which ensued among the healthy from contact with strangers had a more or less definite type; and that type in each case must have been determined mainly by the antecedents of the strangers, their racial characters being reckoned among the antecedents as well as their special hardships and their personal habits. In the case of the singular visitation of England in 1485, the strangers were a swarm of disreputable free-booters from Normandy, natives of a soil which developed the sweat as an indigenous malady in the long course of generations. If they themselves had shown the symptoms of the sweat in 1485, one might have said that the circumstances of their passage in crowded ships, of their exhausting march from Wales to Leicestershire, and thence to London, had brought to the definite issue of a specific disease that which was otherwise no more than a habit of body, a constitutional tendency, a disease in the making. But there is no reason to suppose that they themselves incurred the symptoms of the disease at all; it was contact with them in England, particularly in London, that determined the peculiar type of disease in others. Those others were of a different national stock, and for the most part of another manner of life; in their very differences lay their liability, according to well-known analogies. Of course there must have been something material, something more than abstract contact, to cause the sweat in certain Englishmen; and although we cannot image the form of the virulent matter, we are safe to pronounce, in this hypothesis, that it must have come from the persons of the foreign soldiery. The Habitat of the Virus. We may go even farther in the way of specific probability, and bring the virus definitely to a habitat in the soil. The English sweat, like the Picardy sweat itself, had certain characters of a soil poison, like the poison of cholera, yellow fever and typhoid fever; only it was not endemic like the two last, but periodic, as well as somewhat volatile in its manner of travelling, like dengue, influenza, and others of the “posting” fevers of former times. This brings us to the singular history of the epidemics of sweat in England,--to the clear intervals of many years and the sudden bursting forth anew. What became of the specific virus from 1485 to 1508, to 1517 to 1528, to 1551, and after? A fresh importation in each of the epidemic years after 1485 is improbable; certainly the circumstances of Henry VII.’s expedition never occurred again, and the traffic between England and her two French possessions of Calais and Guines had nothing in it at all analogous. Equally improbable is the continuance of the sweat in isolated or sporadic cases from year to year throughout the intervals between the epidemics; the only facts that give any countenance to such a continuous succession are the occasionally mentioned “hot agues,” as in 1518, and, on a more extensive scale, in 1539. The seeds or germs of the infection which arose first in London in September, 1485, must have lain dormant in the city until some favouring conditions came round to call them into life. It is impossible to figure such dormancy of the virus except on the hypothesis that it was a soil-poison, having its habitat in the pores of the ground. The periodic activity of all such poisons depends, as we can now say with a good deal of certainty, upon the movements of the ground-water, which in turn depend on the wetness or dryness of seasons. The kind of weather preceding each of the epidemics of the English sweat has been remarked on by writers, but somewhat loosely or erroneously. The peculiarity of the year of the second sweat, 1508, (not 1506 as in Hecker, nor 1507 as in other writers) was a “marvellous” forwardness of vegetation in the month of January, unusual heat from the end of May to the 13th of June, much prized rain on that date, on the 16th, and on the 3rd of July[535], the sweat being heard of first in the Lord Treasurer’s household in July. The third year of the sweat, 1517, began with a great frost from the 12th January, so that no boat could go from London to Westminster all the term time[536], while men crossed with horse and cart from Westminster to Lambeth[537]. This great frost would appear to have been without snow, the whole season from September, 1516, to May, 1517, being chronicled as one of unusual drought, “for there fell no rain to be accounted,” so that “in some places men were fain to drive their cattle three or four miles to water.” The kind of weather following the break-up of the drought is not mentioned, but there is implied of course a certain amount of rain. It was about the end of July or first of August, 1517, that the sweat began in London and the suburbs. The fourth, and perhaps the most severe sweat, that of 1528, followed upon two wet seasons, with one spoiled harvest in 1527 and bad prospects for that of 1528. The winter of 1526-27 had been unusually wet from November until the end of January; then dry weather set in until April; after which the rain began again and continued for eight weeks[538]. The harvest before that seems to have been a partial failure, for early in 1527 corn began to run short in London, and for a week or more there was acute general famine, so that the bread carts coming in from Stratford had to be guarded by the sheriffs and their men all the way from Mile End to their proper market. The high price of corn continued into the summer of 1528. The weather of that summer is not specially recorded for England; but we learn from a diplomatic letter dated, Paris, the 4th of July, that much rain had fallen and destroyed the corn and vines, so that there were fears of universal decay and dearth through all France[539]. On the 5th July, Henry VIII. requests Wolsey to have general processions made through the realm “for good weather and for the plague,” the sweat having already been raging for more than a month. The fifth and last sweat, in 1551, also coincided with an unusually high price of corn, or, in other words, followed one or more bad harvests. In 1550 wheat was at 20 shillings the quarter; at Easter in 1551 the price in London was 26_sh._ 8_d._; ten or twelve ship loads of rye and wheat from Holland and Brittany were sold under the mayor’s direction at a stated but very high price. Meanwhile the sweat was advancing from Shrewsbury to London, where it broke out on the 7th July. The statements of Dr Caius about stinking mists carried from town to town are, like most of his statements, so obviously the product of his uncritical rhetoric that it becomes almost impossible to trust his narrative for matters of fact. But we may go so far as to assume that the first half of 1551 was a season of an unusually moist atmosphere. At all events the fifth season of the sweat, and also the fourth (1528), stand out in the annals as years of scarcity following bad harvests, which had probably failed owing to continuous wet weather. There is not, on the surface, much uniformity in the weather preceding the epidemics of the sweat in 1508, 1517, 1528 and 1551. In the first of these the winter was mild and the early summer excessively hot and dry; in the second the winter and spring were remarkable for drought, with several weeks of intense black frost in the middle period; in the remaining two the antecedent appears to have been an excessive rainfall. But in all the four we shall find that the law of the sub-soil water, as formulated by the recent Munich school with reference to epidemic outbursts, was exemplified. According to that law, the dangerous products of fermentation arise from the soil when the pores of the ground are either getting filled with water after having been long filled with air, or are getting filled with air after having been long filled with water. It is the range of fluctuation in the ground-water, either downwards or upwards, that determines the risk to health; and in two of the years of the sweat, 1508 and 1517, we find that there had been a rise from a very low level of the wells, while in the other two, 1528 and 1551, the wells had begun to fall after standing for a length of time at an unusually high level. If this reading of the somewhat imperfect data can be trusted, it is at one and the same time an explanation of the outbreak of the sweat in the respective seasons, and a confirmation of the hypothesis that the virus of the sweat had its habitat in the ground. That hypothesis is, indeed, supported by so great a convergence of probabilities, both for the English sweat and for the endemic sweat of France[540], that it may be used to explain the seasonal incidence without laying the argument open to the charge of running in a vicious circle. Whatever had been the kind of weather determining the successive outbreaks of the sweat, it is clear that the favouring circumstances were in general not the same as those of the bubo-plague. The greater outbursts of plague, as we shall see, were in 1500, 1509, 1513, 1531, 1535, 1543, 1547, and other years not sweat-years. It is only in the autumn of 1517 that the plague overlaps somewhat on the sweat, and even then it becomes noticeable mostly in the winter following the decline of the sweat. The two poisons had existed in English soil side by side, but had not come out at the same seasons; also the sweat had been mostly a disease of the greater houses, and the plague mostly of the poorer. The Extinction of the Sweat in England. The disappearance of the sweat from England after 1551, or its failure to come out again with the appropriate weather, is one of those phenomena of epidemic disease which might be made to appear less of a mystery by finding several more in the like case. A history of all the extinct types of infective disease would probably bring to light some reason why they had each and all died out. But an epidemic disease leaves no bones behind it in the strata; nor has the astonishing progress of science succeeded as yet in detecting palæozoic bacteria, although that discovery cannot be delayed much longer. Meanwhile we have to make what we can of the ordinary records. In our own time, so to speak, the sweat became extinct in 1551, and the plague in 1666; perhaps someone before long may be able to say that typhus died out (for a time) in Britain in such and such a year, and smallpox (for good) in such and such another. The surprising thing is that an infection which came forth time after time should have one day been missed as if it were dead. If the sweat had five seasons in England, why not fifty? Perhaps its career was short because the circumstances of its origin were transient and, as it were, accidental. But it may have been also subject to the only law of extinct disease-species which our scanty knowledge points to--the law of the succession, or superseding, or supplanting of one epidemic type by another. Other forms of epidemic fever, in the same pestilential class as the sweat, were coming to the front in England as well as in other parts of Europe. Thus, in 1539, a summer of great heat and drought, “divers and many honest persons died of the hot agues, and of a great laske through the realm.” The hot agues were febrile influenzas, and the great laske was dysentery. Again, in the autumn of 1557, there died “many of the wealthiest men all England through by a strange fever,” according to one writer[541], or, according to another[542], there prevailed “divers strange and new sicknesses, taking men and women in their heads, as strange agues and fevers, whereof many died.” Jones in his _Dyall of Agues_, describes his own attack near Southampton, in 1558, and calls it the sweating sickness. That epidemic corresponded to a great prevalence of “influenza” on the continent, which was probably as Protean or composite as the fevers in England. It would not be correct to say that these new fevers or influenzas, with more or less of a sweating type, were the sweat somewhat modified. But they seem to have come in succession to the sweat, if not to have taken its place, or supplanted it. The prevalent types of disease somehow reflect the social condition of the population; they change with the social state of the country or of a group of countries; they depend upon a great number of associated circumstances which it would be hard to enumerate exhaustively. As early as 1522 we have the gaol fever at Cambridge, at a time when Henry VIII.’s attempts to repress crime were come to the strange pass described in More’s _Utopia_. These things remain for more systematic handling in another chapter; but in concluding the career of the sweat in England we may pass from it with the remark that it did not cease until other forms of pestilential fever were ready to take its place. The same explanation remains to be given of the total disappearance of plague from England after 1666: it was superseded by pestilential contagious fever, a disease which was its congener, and had been establishing itself more and more steadily from year to year as the conditions of living in the towns were passing more and more from the medieval type to the modern. Meanwhile we have to take up the thread of the plague-history where we left it in the reign of Edward IV.